Azimilide 2HCl

Catalog No. Size PriceQuantity
M7292-2 2mg solid $105
M7292-10 10mg solid $315


Azimilide 2HCl, a class III antiarrhythmic compound, blocks the Kv7.1 and Kv11.1 patassium channels. It also inhibits Na+/Ca2+ exchanger in vitro.

Product information

CAS Number: 149888-94-8

Molecular Weight: 530.88

Formula: C23H30Cl3N5O3


Azimilide Dihydrochloride

NE-10064 Dihydrochloride

Chemical Name: 2,4-Imidazolidinedione, 1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-, dihydrochloride

Smiles: Cl.Cl.CN1CCN(CCCCN2C(=O)N(CC2=O)/N=C/C2=CC=C(O2)C2C=CC(Cl)=CC=2)CC1


InChi: InChI=1S/C23H28ClN5O3.2ClH/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18;;/h4-9,16H,2-3,10-15,17H2,1H3;2*1H/b25-16+;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 2.22 mg/mL (4.18 mM; Need ultrasonic) DMSO : 1.67 mg/mL (3.15 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Azimilide has shown excellent efficacy (>85%) in suppressing supraventricular arrhythmias in a variety of dog models. It also suppressed complex ventricular arrhythmias in infarcted dogs and, in a sudden death cardiac model, decreased mortality[1].


  1. Karam R , Marcello S , Brooks R R , et al. Azimilide Dihydrochloride, a Novel Antiarrhythmic Agent[J]. American Journal of Cardiology, 1998, 81(6-supp-S1):40-46.
  2. Abrol R , Page R L . Azimilide dihydrochloride: a new class III anti-arrhythmic agent[J]. Expert Opinion on Investigational Drugs, 2000, 9(11):2705-2715.
  3. Busch AE, et al. Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action. Br J Pharmacol. 1998 Jan;123(1):23-30.
  4. Yao JA, et al. Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: dependence on blockade of K, Ca, and Na channels. J Cardiovasc Electrophysiol. 1997 Feb;8(2):184-98.
  5. Fermini B, et al. Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents. J Cardiovasc Pharmacol. 1995 Aug;26(2):259-71.
  6. Black SC, et al. Protection against programmed electrical stimulation-induced ventricular tachycardia and sudden cardiac death by NE-10064, a class III antiarrhythmic drug. J Cardiovasc Pharmacol. 1993 Dec;22(6):810-8.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed