Bay K 8644 is a potent selective activator of L-type Ca2 channel with IC50 of 173 nM
CAS Number: 71145-03-4
Molecular Weight: 356.30
Chemical Name: methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 71 mg/mL(199.27 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel.
Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.
- Hernández MC，et al. J Auton Pharmacol. 1995, 15(4):257-269.
- Sulayma A. Albarwani,et al. Front Physiol. 2016, 7:171.
- A J Gonzales,et al. Br J Pharmacol. 1989, 96(2):333-340
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