BAY K 8644

Catalog No. Size PriceQuantity
M7316-2 2mg solid $95
M7316-10 10mg solid $285


Bay K 8644 is a potent selective activator of L-type Ca2 channel with IC50 of 173 nM

Product information

CAS Number: 71145-03-4

Molecular Weight: 356.30

Formula: C16H15F3N2O4

Chemical Name: methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

Smiles: COC(=O)C1C(C(=C(C)NC=1C)[N+]([O-])=O)C1=CC=CC=C1C(F)(F)F


InChi: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 71 mg/mL(199.27 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel.

In Vivo:

Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.


  1. Hernández MC,et al. J Auton Pharmacol. 1995, 15(4):257-269.
  2. Sulayma A. Albarwani,et al. Front Physiol. 2016, 7:171.
  3. A J Gonzales,et al. Br J Pharmacol. 1989, 96(2):333-340

Products are for research use only. Not for human use.

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