LY2365109 HCl


Catalog No. Size PriceQuantity
M7317-2 2mg solid $85
M7317-10 10mg solid $255

Description

LY2365109 is a selective inhibitor of GlyT1 with IC50 of 158 nM

Product information

CAS Number: 1779796-27-8

Molecular Weight: 421.91

Formula: C22H28ClNO5

Chemical Name: N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride

Smiles: Cl.CN(CC(O)=O)CCOC1=CC=C(C=C1C(C)(C)C)C1=CC2OCOC=2C=C1

InChiKey: ZQVOAGQZHDAFRM-UHFFFAOYSA-N

InChi: InChI=1S/C22H27NO5.ClH/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25;/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.
  2. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.

Products are for research use only. Not for human use.

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