CCI-006


Catalog No. Size PriceQuantity
M7364-2 2mg solid $85
M7364-10 10mg solid $255

Description

CCI-006 is a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias, inhibiting mitochondrial respiration and inducing mitochondrial membrane depolarization and apoptosis in a subset (7/11, 64%) of MLL-rearranged leukemia cell lines within a few hours of treatment.

Product information

CAS Number: 292053-42-0

Molecular Weight: 332.33

Formula: C15H12N2O5S

Chemical Name: methyl (E)-2-cyano-3-(5-(4-sulfamoylphenyl)furan-2-yl)acrylate

Smiles: COC(=O)/C(=C/C1=CC=C(O1)C1=CC=C(C=C1)S(N)(=O)=O)/C#N

InChiKey: VEXAKEBSBMAIOB-DHZHZOJOSA-N

InChi: InChI=1S/C15H12N2O5S/c1-21-15(18)11(9-16)8-12-4-7-14(22-12)10-2-5-13(6-3-10)23(17,19)20/h2-8H,1H3,(H2,17,19,20)/b11-8+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 83.33 mg/mL (250.74 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.

Products are for research use only. Not for human use.

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