HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.
CAS Number: 341-88-8
Molecular Weight: 259.34
Chemical Name: 2-heptyl-4-hydroxyquinoline 1-oxide
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 9 mg/mL(34.7 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including Yarrowia lipolytica, S. cerevisiae, Gluconobacter oxydans, T. gondii, P. falciparum, and S. aureus. HQNO targets the Q-site of NDH-2. HQNO concentrations are varied from 0 to 100 μM and 0 to 300 μM for wild-type (WT) and I379E C. thermarum NDH-2 variant, respectively to determine IC50 values. WT NDH-2 has an IC50 value of 10.5±1.3 μM HQNO in the presence of 400 μM Menadione (MD). In the presence of 50 μM MD, the IC50 value for HQNO decreases slightly to 7.3±1.2 μM and near complete inhibition (~15% residual activity) is observed with >50 μM HQNO. At 50 μM MD, HQNO inhibition is observed with an IC50 value of 54.3±1.2 μM.
- N J Jacobs, et al. Evidence for Involvement of the Electron Transport System at a Late Step of Anaerobic Microbial Heme Synthesis. Biochim Biophys Acta. 1977 Jan 6;459(1):141-4.
- Jessica Petri, et al. Structure of the NDH-2 - HQNO Inhibited Complex Provides Molecular Insight Into Quinone-Binding Site Inhibitors. Biochim Biophys Acta Bioenerg. 2018 Jul;1859(7):482-490.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.