Catalog No. Size PriceQuantity
M7366-2 2mg solid $80
M7366-10 10mg solid $240


m-3M3FBS is a novel phospholipase C activator. It can be developed as a novel anti-leukemic agent.

Product information

CAS Number: 200933-14-8

Molecular Weight: 343.36

Formula: C16H16F3NO2S

Chemical Name: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide

Smiles: CC1C=C(C)C=C(C)C=1S(=O)(=O)NC1=CC(=CC=C1)C(F)(F)F


InChi: InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (291.24 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells. m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis.


  1. Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63(5):1043-1050.
  2. Krjukova J, et al. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol. 2004;143(1):3-7.
  3. Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222(2):227-235.

Products are for research use only. Not for human use.

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