Catalog No. Size PriceQuantity
M7393-2 2 mg solid $60
M7393-10 10 mg solid $95
M7393-100 100mg solid $1,530
M7393-100 100 mg solid $435
M7393-C Contact for quotation $100Unavailable


ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM.

Product information

CAS Number: 548470-11-7

Molecular Weight: 451.34

Formula: C22H24Cl2N2O4

Chemical Name: 2-(4-Chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide

Smiles: O=C(COC1C=CC(Cl)=CC=1)NC1CCC(CC1)NC(=O)COC1C=CC(Cl)=CC=1


InChi: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 10 mg/mL(22.15 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Carmela Sidrauski, et al. Elife. 2013 May 28;2:e00498.

Products are for research use only. Not for human use.

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