Alsterpaullone


Catalog No. Size PriceQuantity
M7397-2 2mg solid $100
M7397-10 10mg solid $340
M7397-100 100mg solid $2,280

Description

Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.

Product information

CAS Number: 237430-03-4

Molecular Weight: 293.28

Formula: C16H11N3O3

Chemical Name: 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one

Smiles: [O-][N+](=O)C1=CC=C2NC3=C(CC(=O)NC4=CC=CC=C43)C2=C1

InChiKey: OLUKILHGKRVDCT-UHFFFAOYSA-N

InChi: InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Tyler Lahusen, et al. Mol Carcinog. 2003 Apr;36(4):183-94.
  2. M Leost, et al. Eur J Biochem. 2000 Oct;267(19):5983-94.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed