TMPyP4 tosylate

Catalog No. Size PriceQuantity
M7404-2 2mg solid $80
M7404-10 10mg solid $240
M7404-100 100mg solid $1,440


TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects.

Product information

CAS Number: 36951-72-1

Molecular Weight: 1363.60

Formula: C72H66N8O12S4

Chemical Name: 1-methyl-4-[7,12,17-tris(1-methylpyridin-1-ium-4-yl)-21,22,23,24-tetraazapentacyclo[,.1,.1,]tetracosa-1,3(24),4,6,8,10,12,14,16(22),17,19-undecaen-2-yl]pyridin-1-ium tetrakis(4-methylbenzene-1-sulfonate)

Smiles: C[N+]1C=CC(=CC=1)C1C2C=CC(N=2)=C(C2=CC=C(N2)C(=C2C=CC(=N2)C(=C2C=CC=1N2)C1C=C[N+](C)=CC=1)C1C=C[N+](C)=CC=1)C1C=C[N+](C)=CC=1.CC1C=CC(=CC=1)S([O-])(=O)=O.CC1C=CC(=CC=1)S([O-])(=O)=O.CC1C=CC(=CC=1)S([O-])(=O)=O.CC1C=CC(=CC=1)S([O-])(=O)=O


InChi: InChI=1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40-;;;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 10 mg/mL (7.33 mM; Need ultrasonic) H2O : 6.2 mg/mL (4.55 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Chen H, et al. Insuline-like growth factor type I selectively binds to G-quadruplex structures. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):31-38.
  2. Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11.

Products are for research use only. Not for human use.

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