BRD0539 is a potent inhibitor of Streptococcus pyogenes Cas9 (SpCas9) with IC50 of 22 μM in an in vitro DNA cleavage assay.
CAS Number: 1403838-79-8
Molecular Weight: 452.54
Chemical Name: (3aR, 4R, 9bR)-8-(2-Fluorophenyl)-2, 3, 3a, 4, 5, 9b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[3, 2-c]quinoline-4-methanol
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 91 mg/mL(201.08 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
BRD0539 is stable in human plasma and reversibly inhibits SpCas9. BRD0539 does not interfere with the SpCas9:gRNA interaction. BRD0539 dose-dependently blocks the formation of the DNA-bound state in a dose-dependent fashion. BRD0539 impairs the perturbation induced by the 4PAM DNA. BRD0539 is able to inhibit SpCas9 in the eGFP-disruption assay.
- Basudeb Maji, et al. Cell. 2019 May 2;177(4):1067-1079.e19.
Products are for research use only. Not for human use.
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