Fluzoparib (SHR-3162)


Catalog No. Size PriceQuantity
M7407-2 2mg solid $105
M7407-10 10mg solid $375
M7407-100 100mg solid $2,625

Description

Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity.

Product information

CAS Number: 1358715-18-0

Molecular Weight: 472.40

Formula: C22H16F4N6O2

Chemical Name: 4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one

Smiles: O=C1NN=C(CC2C=C(C(F)=CC=2)C(=O)N2CC3=NC(=NN3CC2)C(F)(F)F)C2=CC=CC=C12

InChiKey: XJGXCBHXFWBOTN-UHFFFAOYSA-N

InChi: InChI=1S/C22H16F4N6O2/c23-16-6-5-12(10-17-13-3-1-2-4-14(13)19(33)29-28-17)9-15(16)20(34)31-7-8-32-18(11-31)27-21(30-32)22(24,25)26/h1-6,9H,7-8,10-11H2,(H,29,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 94 mg/mL(198.98 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

All four NSCLC cell lines (A549, H460, H1299, and PC9) shows decreased viability upon exposure to fluzoparib, and the effect is time and dose dependent. Fluzoparib acts synergistically to inhibit cell growth and promote apoptosis among lung cancer cells.

In Vivo:

An H460 cell xenograft mouse model is established to study the in vivo effects of fluzoparib and RT on tumor growth and survival. Treatment with RT + fluzoparib more effectively delayed tumor growth than treatment with either RT or fluzoparib individually. When combined with RT, fluzoparib conferres a significant survival benefit with no evidence of toxicity.

References:

  1. Jing Luo, et al. J Cancer Res Clin Oncol. 2020 Mar;146(3):721-737.
  2. Ye Han, et al. Am J Cancer Res. 2019 Mar 1;9(3):608-618.

Products are for research use only. Not for human use.

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