Catalog No. Size PriceQuantity
M7422-2 2mg solid $100
M7422-10 10mg solid $300
M7422-100 100mg solid $1,800


ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.

Product information

CAS Number: 41443-28-1

Molecular Weight: 187.15

Formula: C9H5N3O2

Chemical Name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Smiles: O=C1ON=C2C=NC3=CC=CC=C3N21


InChi: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 37 mg/mL(197.7 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

In vitro, administration of H2O2 (for 4 hrs) to rat cardiomyoblasts decreases mitochondrial respiration attributable to generation of hydroxyl radicals. Pretreatment of cells with ODQ does not abolish this cell injury. In addition, ODQ does not scavenge superoxide anions.

In Vivo:

Pretreatment of rats with ODQ attenuates the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide.


  1. K Zacharowski, et al. Crit Care Med. 2001 Aug;29(8):1599-608.

Products are for research use only. Not for human use.

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