Larotrectinib

Larotrectinib (Vitrakvi, LOXO-101, ARRY-470) is an ATP-competitive, oral administered and highly selective inhibitor of the tropomyosin-related kinase (TRK) family receptors.

Product information

CAS Number: 1223403-58-4

Molecular Weight: 428.44

Formula: C21H22F2N6O2

Synonym:

Vitrakvi

LOXO-101

ARRY-470

Chemical Name: (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

Smiles: O[C@@H]1CN(CC1)C(=O)NC1C=NN2C=CC(=NC2=1)N1CCC[C@@H]1C1=CC(F)=CC=C1F

InChiKey: NYNZQNWKBKUAII-KBXCAEBGSA-N

InChi: InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Robert C Doebele, et al. Cancer Discov. 2015 Oct;5(10):1049-5

Products are for research use only. Not for human use.