E260


Catalog No. Size PriceQuantity
M7437-2 2mg solid $340
M7437-10 10mg solid $1,360
M7437-100 100mg solid $10,880

Description

E260 (Fer and FerT inhibitor E260) is a Fer kinase and FerT inhibitor that selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP level.

Product information

CAS Number: 1241537-79-0

Molecular Weight: 438.63

Formula: C24H34N6S

Synonym:

Fer/FerT inhibitor E260

Chemical Name: 6-(4-Isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole

Smiles: CN1CCN(CC2CCN(CC2)C2=NN3C=C(N=C3S2)C2C=CC(=CC=2)C(C)C)CC1

InChiKey: RFHSWNJYHRAOMP-UHFFFAOYSA-N

InChi: InChI=1S/C24H34N6S/c1-18(2)20-4-6-21(7-5-20)22-17-30-23(25-22)31-24(26-30)29-10-8-19(9-11-29)16-28-14-12-27(3)13-15-28/h4-7,17-19H,8-16H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Ethanol 15 mg/mL (34.20 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Yoav Elkis, et al. Nat Commun. 2017 Oct 16;8(1):940.

Products are for research use only. Not for human use.

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