Description
E260 (Fer and FerT inhibitor E260) is a Fer kinase and FerT inhibitor that selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP level.
Product information
CAS Number: 1241537-79-0
Molecular Weight: 438.63
Formula: C24H34N6S
Synonym:
Fer/FerT inhibitor E260
Chemical Name: 6-(4-Isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole
Smiles: CN1CCN(CC2CCN(CC2)C2=NN3C=C(N=C3S2)C2C=CC(=CC=2)C(C)C)CC1
InChiKey: RFHSWNJYHRAOMP-UHFFFAOYSA-N
InChi: InChI=1S/C24H34N6S/c1-18(2)20-4-6-21(7-5-20)22-17-30-23(25-22)31-24(26-30)29-10-8-19(9-11-29)16-28-14-12-27(3)13-15-28/h4-7,17-19H,8-16H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Ethanol 15 mg/mL (34.20 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Yoav Elkis, et al. Nat Commun. 2017 Oct 16;8(1):940.
Products are for research use only. Not for human use.
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