L-2-Hydroxyglutaric acid disodium


Catalog No. Size PriceQuantity
M7450-2 2mg solid $75
M7450-10 10mg solid $225
M7450-100 100mg solid $1,350

Description

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Product information

CAS Number: 63512-50-5

Molecular Weight: 192.08

Formula: C5H6Na2O5

Synonym:

(S)-2-Hydroxyglutaric acid disodium

L-2-Hydroxyglutarate disodium

LGA

L-2HG

Chemical Name: disodium;(2S)-2-hydroxypentanedioate

Smiles: [Na+].[Na+].[O-]C(=O)CC[C@H](O)C([O-])=O

InChiKey: DZHFTEDSQFPDPP-QTNFYWBSSA-L

InChi: InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Water 38 mg/mL (197.83 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Eun-Hee Shim, et al. Cancer Discov. 2014 Nov;4(11):1290-8.
  2. Cleide G da Silva, et al. Int J Dev Neurosci. 2003 Jun;21(4):217

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed