L-2-Hydroxyglutaric acid disodium

Catalog No. Size PriceQuantity
M7450-2 2mg solid $75
M7450-10 10mg solid $225
M7450-100 100mg solid $1,350


L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Product information

CAS Number: 63512-50-5

Molecular Weight: 192.08

Formula: C5H6Na2O5


(S)-2-Hydroxyglutaric acid disodium

L-2-Hydroxyglutarate disodium



Chemical Name: disodium;(2S)-2-hydroxypentanedioate

Smiles: [Na+].[Na+].[O-]C(=O)CC[C@H](O)C([O-])=O


InChi: InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Water 38 mg/mL (197.83 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Eun-Hee Shim, et al. Cancer Discov. 2014 Nov;4(11):1290-8.
  2. Cleide G da Silva, et al. Int J Dev Neurosci. 2003 Jun;21(4):217

Products are for research use only. Not for human use.

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