Catalog No. Size PriceQuantity
M7471-2 2mg solid $100
M7471-10 10mg solid $300


ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.

Product information

CAS Number: 2254001-81-3

Molecular Weight: 414.40

Formula: C22H20F2N2O4

Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid

Smiles: CC[C@@H](OC1=NC(OC2=CC(=CC=C2)C2=CC(CN)=CC=C2)=C(F)C=C1F)C(O)=O


InChi: InChI=1S/C22H20F2N2O4/c1-2-19(22(27)28)30-21-18(24)11-17(23)20(26-21)29-16-8-4-7-15(10-16)14-6-3-5-13(9-14)12-25/h3-11,19H,2,12,25H2,1H3,(H,27,28)/t19-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 86 mg/mL (207.53 mM) Ethanol 86 mg/mL (207.53 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Imadul Islam, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3

Products are for research use only. Not for human use.

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