ZK824859


Catalog No. Size PriceQuantity
M7471-2 2mg solid $100
M7471-10 10mg solid $300

Description

ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.

Product information

CAS Number: 2254001-81-3

Molecular Weight: 428.43

Formula: C23H22F2N2O4

Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid

Smiles: CC1C=C(C=C(C=1)OC1=NC(O[C@H](CC)C(O)=O)=C(F)C=C1F)C1=CC(CN)=CC=C1

InChiKey: CVNXUNVHFJANHX-HXUWFJFHSA-N

InChi: InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 86 mg/mL (207.53 mM) Ethanol 86 mg/mL (207.53 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Imadul Islam, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3

Products are for research use only. Not for human use.

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