Description
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
Product information
CAS Number: 2254001-81-3
Molecular Weight: 414.40
Formula: C22H20F2N2O4
Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid
Smiles: CC[C@@H](OC1=NC(OC2=CC(=CC=C2)C2=CC(CN)=CC=C2)=C(F)C=C1F)C(O)=O
InChiKey: ZDHMLADHONAIES-LJQANCHMSA-N
InChi: InChI=1S/C22H20F2N2O4/c1-2-19(22(27)28)30-21-18(24)11-17(23)20(26-21)29-16-8-4-7-15(10-16)14-6-3-5-13(9-14)12-25/h3-11,19H,2,12,25H2,1H3,(H,27,28)/t19-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 86 mg/mL (207.53 mM) Ethanol 86 mg/mL (207.53 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Imadul Islam, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3
Products are for research use only. Not for human use.
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