MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase.
CAS Number: 88191-84-8
Molecular Weight: 382.45
Calpain Inhibitor III
Chemical Name: benzyl ((2S)-3-methyl-1-oxo-1-((1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 76 mg/mL (198.72 mM) Ethanol 10 mg/mL (26.15 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
MDL28170 significantly enhances Schwann cells (SCs) survival in vitro in response to oxidative stress induced by application of H2O2, without reducing LDH release.
MDL 28170 is a calpain inhibitor that protects against cortical neuronal damage even if the treatment is delayed until 3 h after reperfusion. However, the neuroprotective effect of this agent is less pronounced in the hippocampal CA1 sector.
- P A Li, et al. Neurosci Lett. 1998 May 8;247(1):17-20.
- Yosuke Tona, et al. BMC Neurosci. 2014 May 22;15:66.
- Caitlin E Hill, et al. J Neurotrauma. 2010 Sep;27(9):1685-95.
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