Catalog No. Size PriceQuantity
M7479-2 2mg solid $105
M7479-10 10mg solid $360


MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase.

Product information

CAS Number: 88191-84-8

Molecular Weight: 382.45

Formula: C22H26N2O4


Calpain Inhibitor III

Chemical Name: benzyl ((2S)-3-methyl-1-oxo-1-((1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

Smiles: CC(C)[C@H](NC(=O)OCC1C=CC=CC=1)C(=O)NC(CC1C=CC=CC=1)C=O


InChi: InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 76 mg/mL (198.72 mM) Ethanol 10 mg/mL (26.15 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MDL28170 significantly enhances Schwann cells (SCs) survival in vitro in response to oxidative stress induced by application of H2O2, without reducing LDH release.

In Vivo:

MDL 28170 is a calpain inhibitor that protects against cortical neuronal damage even if the treatment is delayed until 3 h after reperfusion. However, the neuroprotective effect of this agent is less pronounced in the hippocampal CA1 sector.


  1. P A Li, et al. Neurosci Lett. 1998 May 8;247(1):17-20.
  2. Yosuke Tona, et al. BMC Neurosci. 2014 May 22;15:66.
  3. Caitlin E Hill, et al. J Neurotrauma. 2010 Sep;27(9):1685-95.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed