Catalog No. Size PriceQuantity
M7498-2 2mg solid $80
M7498-10 10mg solid $240


ML281 is a potent and selective inhibitor of Serine/threonine kinase 33 (STK33) with IC50 of 0.014 μM. ML281 is selectively toxic to KRAS-dependent cancer cell lines.

Product information

CAS Number: 1404437-62-2

Molecular Weight: 389.47

Formula: C22H19N3O2S

Chemical Name: N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide

Smiles: CC(C)C1=CC(C2=NC3=CC=CC=C3NC2=O)=C(C=C1)NC(=O)C1=CC=CS1


InChi: InChI=1S/C22H19N3O2S/c1-13(2)14-9-10-16(24-21(26)19-8-5-11-28-19)15(12-14)20-22(27)25-18-7-4-3-6-17(18)23-20/h3-13H,1-2H3,(H,24,26)(H,25,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 78 mg/mL (200.27 mM) Ethanol 3 mg/mL (7.70 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Michel Weïwer, et al. ACS Med Chem Lett. 2012 Dec 13;3(12):1

Products are for research use only. Not for human use.

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