Catalog No. Size PriceQuantity
M7513-2 2mg solid $100
M7513-10 10mg solid $310


XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN, respectively.

Product information

CAS Number: 898280-07-4

Molecular Weight: 437.54

Formula: C22H31N9O

Chemical Name: N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

Smiles: CN1CCN(CC1)C1=CC(NC2C=C(NN=2)C2CC2)=NC(NCC2=CC(=NO2)C(C)C)=N1


InChi: InChI=1S/C22H31N9O/c1-14(2)17-10-16(32-29-17)13-23-22-25-19(24-20-11-18(27-28-20)15-4-5-15)12-21(26-22)31-8-6-30(3)7-9-31/h10-12,14-15H,4-9,13H2,1-3H3,(H3,23,24,25,26,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 88 mg/mL (201.12 mM) Ethanol 30 mg/mL (68.57 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Jorge Cortes, et al. Blood (2008) 112 (11): 3232.

Products are for research use only. Not for human use.

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