Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.
CAS Number: 300815-04-7
Molecular Weight: 438.65
Chemical Name: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 88 mg/mL (200.62 mM) Ethanol 10 mg/mL (22.80 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Apcin is a novel cell‑permeable molecule that blocks the interaction between APC/C and Cdc20. Apcin is demonstrated to inhibit OS cell growth and induce significant apoptosis. The invasion and mobile abilities of OS cells are also markedly suppressed by apcin treatment. Furthermore, Bim and p21 are upregulated in OS cells following apcin treatment. The inhibition of CDC20 with its inhibitor Apcin reduces the adhesion rate and proliferation ability to RL95-2 and HEC-1A cells, respectively.
CDC20 inhibitor Apcin inhibits embryo implantation in vivo.
- Katharine L Sackton, et al. Nature. 2014 Oct 30;514(7524):646-9.
- Yuan Gao, et al. Oncol Rep. 2018 Aug;40(2):841-848.
- Chuanjia Guo, et al. Cell Biochem Funct. 2020 Aug;38(6):810-81
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