NBQX (FG9202)


Catalog No. Size PriceQuantity
M7541-2 2mg solid $100
M7541-10 10mg solid $355

Description

NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.

Product information

CAS Number: 118876-58-7

Molecular Weight: 336.28

Formula: C12H8N4O6S

Synonym:

FG-9202

FG 9202

NNC 079202

Chemical Name: 6-nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide

Smiles: NS(=O)(=O)C1=CC=CC2=C3NC(=O)C(=O)NC3=CC(=C21)[N+]([O-])=O

InChiKey: UQNAFPHGVPVTAL-UHFFFAOYSA-N

InChi: InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 67 mg/mL (199.24 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NBQX is highly selective in vitro. The IC50 value for inhibition of AMPA-evoked inward currents is 0.4 μM for NBQX. While NBQX inhibits NMDA-induced currents with IC50 value of 60 μM.

In Vivo:

Rats are intraperitoneally (i.p.) injected with pentylenetetrazole (PTZ, 50 mg/kg) for 28 consecutive days to establish chronic epilepsy models. Subsequently, NBQX (20 mg/kg, i.p.) is injected for 3 days for the observation of behavioral measurements of epilepsy. NBQX treatment normalizes perineuronal nets (PNNs), tenascin-R, aggrecan and neurocan levels. NBQX is sufficient to decrease seizures through increasing the latency to seizures, decrease the duration of seizure onset, and reduce the scores for the severity of seizures.

References:

  1. Wen Chen, et al. PLoS One. 2016 Nov 23;11(11):e0166672.
  2. C Mathiesen, et al. Eur J Pharmacol. 1998 Jul 24;353(2-3):159

Products are for research use only. Not for human use.

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