Description
CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.
Product information
CAS Number: 923596-52-5
Molecular Weight: 253.30
Formula: C14H15N5
Chemical Name: N-propyl-3-(pyridin-4-yl)imidazo[1,2-b]pyridazin-6-amine
Smiles: CCCNC1C=CC2=NC=C(C3C=CN=CC=3)N2N=1
InChiKey: XTMROGQLIVGYKF-UHFFFAOYSA-N
InChi: InChI=1S/C14H15N5/c1-2-7-16-13-3-4-14-17-10-12(19(14)18-13)11-5-8-15-9-6-11/h3-6,8-10H,2,7H2,1H3,(H,16,18)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Kazuo Nakai, et al. Fused heterocycles as lck inhibitors. WO2007013673A1.
Products are for research use only. Not for human use.
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