SJF 8240

c-MET PROTAC®Degrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

Product information

CAS Number: 2230821-68-6

Molecular Weight: 1106.24

Formula: C58H65F2N7O11S

Synonym:

SJF-8240

SJF8240

Chemical Name: N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S, 4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3, 3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide

Smiles: CC(C)(C)[C@H](NC(=O)CCOCCCOCCCOC1=CC2=NC=CC(OC3=CC=C(C=C3F)N(C(=O)C3(CC3)C(N)=O)C3C=CC(F)=CC=3)=C2C=C1OC)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1C=CC(=CC=1)C1SC=NC=1C

InChiKey: MCJFROJTDORRBB-ZWUDBOSPSA-N

InChi: InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-64-35)37-10-8-36(9-11-37)32-63-53(70)45-29-41(68)33-66(45)54(71)52(57(2,3)4)65-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-62-44)78-47-17-16-40(28-43(47)60)67(39-14-12-38(59)13-15-39)56(73)58(20-21-58)55(61)72/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H2,61,72)(H,63,70)(H,65,69)/t41-,45+,52-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.