Description
Potent and selective MTH1 inhibitor (IC50 = 2.3 nM). Exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. Cell-permeable and active in vivo. Displays no antitumor activity in vitro or in vivo.
Product information
CAS Number: 2109805-96-9
Molecular Weight: 288.34
Formula: C15H20N4O2
Synonym:
BAY-707
BAY707
BAY-707 free base
Related CAS Number:
2223023-19-4 (BAY-707 acetate)
Chemical Name: N-Ethyl-4-[(3S)-3-methylmorpholin-4-yl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Smiles: CCNC(=O)C1=CC2=C(N1)N=CC=C2N1CCOC[C@@H]1C
InChiKey: RPMGXDCRCWWCRY-JTQLQIEISA-N
InChi: InChI=1S/C15H20N4O2/c1-3-16-15(20)12-8-11-13(4-5-17-14(11)18-12)19-6-7-21-9-10(19)2/h4-5,8,10H,3,6-7,9H2,1-2H3,(H,16,20)(H,17,18)/t10-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Ellermann M, et al. Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.ACS Chem Biol. 2017 Aug 18;12(8):1986-1992.
Products are for research use only. Not for human use.
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