Description
Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity.
Product information
CAS Number: 936339-60-5
Molecular Weight: 358.39
Formula: C21H18N4O2
Synonym:
E-1210
E 1210
APX001A
APX-001-A
APX 001 A
Chemical Name: (3-(3-(4-(((Pyridin-2-yl)oxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-)amine
Smiles: NC1=NC=CC=C1C1=CC(CC2=CC=C(COC3=CC=CC=N3)C=C2)=NO1
InChiKey: WSEKTEUGRLFBSE-UHFFFAOYSA-N
InChi: InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 72 mg/mL(200.89 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Olga Rivero-Menendez, et al. J Antimicrob Chemother. 2019 May 1;74(5):1295-1299.
Products are for research use only. Not for human use.
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