Fulacimstat


Catalog No. Size PriceQuantity
M7600-2 2mg solid $150
M7600-10 10mg solid $450

Description

Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.

Product information

CAS Number: 1488354-15-9

Molecular Weight: 487.38

Formula: C23H16F3N3O6

Synonym:

BAY1142524

BAY-1142524

BAY 1142524

Chemical Name: 1-(3-methyl-2-oxo-2, 3-dihydro-1, 3-benzoxazol-6-yl)- 2, 4-dioxo-3-[(1R)-4-(trifluoromethyl)-2, 3-dihydro-1H-inden- 1-yl]-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylic acid

Smiles: CN1C2=CC=C(C=C2OC1=O)N1C=C(C(O)=O)C(=O)N([C@@H]2CCC3C(=CC=CC=32)C(F)(F)F)C1=O

InChiKey: JDARDSVOVYVQST-MRXNPFEDSA-N

InChi: InChI=1S/C23H16F3N3O6/c1-27-17-7-5-11(9-18(17)35-22(27)34)28-10-14(20(31)32)19(30)29(21(28)33)16-8-6-12-13(16)3-2-4-15(12)23(24,25)26/h2-5,7,9-10,16H,6,8H2,1H3,(H,31,32)/t16-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 97 mg/mL(199.02 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Friederike Kanefendt, et al. Clin Pharmacol Drug Dev. 2019 May;8(4):467-479.
  2. Hanna Tinel, et al. Circulation. November 14, 2017.Vol 136, Issue suppl_1.

Products are for research use only. Not for human use.

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