Methyl-Hesperidin


Catalog No. Size PriceQuantity
M7625-2 2mg solid $120
M7625-10 10mg solid $360

Description

Methyl-Hesperidin is a vasodilating agent[1].

Product information

CAS Number: 11013-97-1

Molecular Weight: 624.59

Formula: C29H36O15

Chemical Name: (2S)-2-(3,4-dimethoxyphenyl)-5-hydroxy-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one

Smiles: C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3=CC(O)=C4C(=O)C[C@H](OC4=C3)C3=CC(OC)=C(C=C3)OC)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

InChiKey: GUMSHIGGVOJLBP-SLRPQMTOSA-N

InChi: InChI=1S/C29H36O15/c1-11-22(32)24(34)26(36)28(41-11)40-10-20-23(33)25(35)27(37)29(44-20)42-13-7-14(30)21-15(31)9-17(43-19(21)8-13)12-4-5-16(38-2)18(6-12)39-3/h4-8,11,17,20,22-30,32-37H,9-10H2,1-3H3/t11-,17-,20+,22-,23+,24+,25-,26+,27+,28+,29+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL(160.1 mM). Water: 100 mg/mL(160.1 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin and methyl hesperidin reduce TNF-alpha-induced VCAM-1 expression through inhibiting the phosphorylation of Akt and PKC. Methyl hesperidin can bind to buman serum albumin (BSA) with binding constants between 18 and 34 mM/L. Long-term carcinogenicity study demonstrates that methyl hesperidin shows no carcinogenicity for B6C3F1 mice in the 96-wk feeding regimen.

References:

  1. Kurata Y, et al. Food Chem Toxicol, 1990, 28(9), 613-618.
  2. Li J, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2013, 102, 200-204.
  3. Nizamutdinova IT, et al. Int Immunopharmacol, 2008, 8(5), 670-678.

Products are for research use only. Not for human use.

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