Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.
CAS Number: 67920-52-9
Molecular Weight: 220.15
Chemical Name: sodium 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 7 mg/mLwarmed(31.79 mM). Water: 2 mg/mL(9.08 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals (HO()), superoxide anion radicals (O(2)(-)), 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than vitamin C. Sodium danshensu shows a biphasic effects on vessel tension. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produces a weak contraction, while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu also inhibits phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium.
LD50: Mice 2356.33 mg/kg (i.g.); Rats >1500mg/kg (i.v.).
- Ren R, et al. Toxicol Mech Methods, 2010, 20(8), 510-514.
- Zhang N, et al. Acta Pharmacol Sin, 2010, 31(4), 421-428.
- Zhao GR, et al. Food Chem Toxicol, 2008, 46(1), 73-81.
Products are for research use only. Not for human use.
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