Chrysophanol


Catalog No. Size PriceQuantity
M7646-2 2mg solid $80
M7646-10 10mg solid $240

Description

Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.

Product information

CAS Number: 481-74-3

Molecular Weight: 254.24

Formula: C15H10O4

Synonym:

Chrysophanic acid

Chemical Name: 1, 8-dihydroxy-3-methyl-9, 10-dihydroanthracene-9, 10-dione

Smiles: CC1C=C(O)C2=C(C=1)C(=O)C1C=CC=C(O)C=1C2=O

InChiKey: LQGUBLBATBMXHT-UHFFFAOYSA-N

InChi: InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 5 mg/mLwarmed(19.66 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor. Chrysophanic acid (Chrysophanol) is a natural anthraquinone, has anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid (Chrysophanol) preferentially blocks proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid (Chrysophanol) treatment in SNU-C5 cells inhibits EGF-induced phosphorylation of EGFR and suppresses activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid also inhibits the replication of poliovirus types 2 and 3 (Picornaviridae) and poliovirus-induced cytopathic effects in BGM (Buffalo green monkey) kidney cells.

References:

  1. Semple SJ, et al. Antiviral Res, 2001, 49(3), 169-178.
  2. Lee MS, et al. Phytother Res, 2011, 25(6), 833-837.

Products are for research use only. Not for human use.

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