Daidzin is an aldehyde dehydrogenase 2 inhibitor. It decreases DNA damage but does not alter transmitter release by cisplatin. Daidzin is also an antidipsotropic agent, and shows potential for the treatment of alcohol dependency.
CAS Number: 552-66-9
Molecular Weight: 416.38
Chemical Name: 3-(4-Hydroxyphenyl)-7-[(2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 83 mg/mL(199.33 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Daidzin has no effect on alcohol-metabolizing enzymes(i.e., ADH and ALDH) when given to rats intragastrically. Chronic daidzin administration exerts an effect on alcohol pharmacokinetics, although the effect is less pronounced than when the compound is administered concurrently with ethanol.The compound is shown to shorten sleep time if ethanol is given intragastrically, but not when given intraperitoneally, indicating absence of effect on ethanol elimination rate. Daidzin delays ethanol absorption and lessens alcohol intoxication. The compound is shown to suppress the levels of BAC(blood alcohol concentration) for the first 3 hr after alcohol ingestion in both fasted and fed rats. These effects of daidzin may in part be due to its antioxidant activity.
- Keung WM, et al. Proc Natl Acad Sci U S A. 1993, 90(4):1247-51.
- Xie CI, et al. Alcohol Clin Exp Res. 1994, 18(6):1443-7.
- Oh HJ, et al. Mol Cell Endocrinol. 2013, 376(1-2):107-13.
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