Estradiol


Catalog No. Size PriceQuantity
M7657-2 2mg solid $80
M7657-10 10mg solid $240

Description

Estradiol is an Estrogen. Estradiol is the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.The mechanism of action of estradiol is as an Estrogen Receptor Agonist. Therapeutic Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Typically esterified, estradiol derivatives are formulated for oral or parenteral administration.

Product information

CAS Number: 50-28-2

Molecular Weight: 272.38

Formula: C18H24O2

Synonym:

Beta-Estradiol

17beta-Estradiol

Oestradiol

Estrace

Dihydrofolliculin

β-Estradiol

Estradiol

17β-Oestradiol

Chemical Name: (8R, 9S, 13S, 14S, 17S)-13-methyl-6, 7, 8, 9, 11, 12, 14, 15, 16, 17-decahydrocyclopenta[a]phenanthrene-3, 17-diol

Smiles: C[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=CC=C43)[C@@H]1CC[C@@H]2O

InChiKey: VOXZDWNPVJITMN-ZBRFXRBCSA-N

InChi: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 54 mg/mL(198.25 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. Estradiol treatment resulted in a 46% increase in NMDA receptor binding. Estradiol treatment increases NMDA receptor binding in parallel with dendritic spine and synapse density. Estradiol treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. 17 beta-estradiol is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. 17 beta-estradiol exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria.

In Vivo:

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. Estradiol alone can reverse the ovariectomy-induced decrease in spine density. Estradiol combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following estradiol alone.

References:

  1. Girasole G, et al. J Clin Invest, 1992, 89(3), 883-891.
  2. Mermelstein PG, et al. J Neurosci, 1996, 16(2), 595-604.
  3. Woolley CS, et al. J Neurosci, 1997, 17(5), 1848-1859.

Products are for research use only. Not for human use.

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