Galanthamine hydrobromide


Catalog No. Size PriceQuantity
M7665-2 2mg solid $85
M7665-10 10mg solid $255

Description

Galantamine Hydrobromide is the hydrobromide salt form of galantamine, a tertiary alkaloid with anticholinesterase and neurocognitive-enhancing activities. It is an alkaloid acetylcholinesterase inhibitor. Galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach). This agent may improve neurocognitive function in mild and moderate Alzheimer' s disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse.

Product information

CAS Number: 1953-04-4

Molecular Weight: 368.27

Formula: C17H22BrNO3

Synonym:

Galantamine HBr

Nivalin

Razadyne

Reminyl

Nivaline

Chemical Name: (4aS, 6R, 8aS)-4a, 5, 9, 10, 11, 12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a, 3, 2-ef][2]benzazepin-6-ol hydrobromide

Smiles: Br.COC1=CC=C2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3OC1=C42

InChiKey: QORVDGQLPPAFRS-XPSHAMGMSA-N

InChi: InChI=1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Water 10 mg/mL (27.15 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells.

In Vivo:

Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia.

References:

  1. Thomsen T, et al. Eur J Clin Chem Clin Biochem, 1991, 29(8), 487-492.
  2. Pereira EF, et al. J Pharmacol Exp Ther, 1994, 270(2), 768-778.
  3. Storch A, et al. Eur J Pharmacol, 1995, 290(3), 207-219.
  4. Lorrio S, et al. J Pharmacol Exp Ther, 2007, 322(2), 591-599.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed