Luteolin is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance. Luteolin belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. Luteolin possesses many beneficial properties including antioxidant, anti- inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions.
CAS Number: 491-70-3
Molecular Weight: 286.24
C.I. Natural Yellow 2
Chemical Name: 2-(3, 4-Dihydroxyphenyl)-5, 7-dihydroxy-4-benzopyrone
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 57 mg/mL (199.13 mM) Ethanol (warmed with 50ºC water bath) 3 mg/mL (10.48 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha.
LD50: Mice >2500mg/kg (i.g.)
- Xagorari A, et al. J Pharmacol Exp Ther, 2001, 296(1), 181-187.
- Yu MC, et al. Eur J Pharmacol, 2010, 627(1-3), 269-275.
Products are for research use only. Not for human use.
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