Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis. Monensin sodium salt is an ionophore that mediates Na+/H+ exchange. Monensin sodium salt causes a marked enlargement of the MVBs and regulates exosome secretion.
CAS Number: 22373-78-0
Molecular Weight: 692.85
Related CAS Number:
Chemical Name: sodium (2S, 3R, 4S)-4-[(2S, 5R, 7S, 8R, 9S)-2-[(2S, 2'R, 3'S, 5R, 5'R)-2-ethyl-5'-[(2S, 3S, 5R, 6R)-6-hydroxy-6-(hydroxymethyl)-3, 5-dimethyloxan-2-yl]-3'-methyl-[2, 2'-bioxolan]-5-yl]-9-hydroxy-2, 8-dimethyl-1, 6-dioxaspiro[4.5]decan-7-yl]-3-methoxy-2-methylpentanoate
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Ethanol 100 mg/mL (144.33 mM) DMSO 1.5 mg/mL (2.16 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes.
LD50: Mice 335mg/kg (i.g.) ; Rats 36.5mg/kg (i.g.); Chickens 185mg/kg (i.g.).
- Huczynski A, et al. Bioorg Med Chem Lett, 2008, 18(8), 2585-2589.
- Mollenhauer HH, et al. Biochim Biophys Acta, 1990, 1031(2), 225-246.
- Pinkerton M, et al. J Mol Biol, 1970, 49(3), 533-546.
Products are for research use only. Not for human use.
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