Catalog No. Size PriceQuantity
M7689-2 2mg solid $80
M7689-10 10mg solid $240


Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.

Product information

CAS Number: 484-12-8

Molecular Weight: 244.29

Formula: C15H16O3





Chemical Name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one

Smiles: CC(C)=CCC1=C2OC(=O)C=CC2=CC=C1OC


InChi: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 49 mg/mL(200.58 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg.

In Vivo:

LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.).


  1. Huang RL, et al. Hepatology, 1996, 24(3), 508-515.
  2. Kuo PL, et al. J Pharmacol Exp Ther, 2005, 314(3), 1290-1299.
  3. Ko FN, et al. Thromb Haemost, 1989, 62(3), 996-999.

Products are for research use only. Not for human use.

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