Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.
CAS Number: 484-12-8
Molecular Weight: 244.29
Chemical Name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 49 mg/mL(200.58 mM). Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg.
LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.).
- Huang RL, et al. Hepatology, 1996, 24(3), 508-515.
- Kuo PL, et al. J Pharmacol Exp Ther, 2005, 314(3), 1290-1299.
- Ko FN, et al. Thromb Haemost, 1989, 62(3), 996-999.
Products are for research use only. Not for human use.
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