Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
CAS Number: 20554-84-1
Molecular Weight: 248.32
Chemical Name: (1S, 2R, 4R, 11S)-4, 8-dimethyl-12-methylidene-3, 14-dioxatricyclo[22.214.171.124, ]tetradec-7-en-13-one
Smiles: CC1CC[C@@H]2[C@H](OC(=O)C2=C)[C@H]2O[C@]2(C)CCC=1 |c:19|
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 49 mg/mL(197.32 mM). Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
- Gopal YN, et al. Mol Cancer Ther. 2009, 8(3):552-62.
- Sheehan M, et al. Mol Pharmacol. 2002, 61(5):953-63.
- Gopal YN, et al. Chem Biol, 2007,14(7):813-23.
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