Sclareol


Catalog No. Size PriceQuantity
M7698-2 2mg solid $80
M7698-10 10mg solid $240

Description

Sclareol is a diterpene compound with a labdane skeleton, is mainly used as a raw material in the fragrance industry. It shows potent cytotoxic and cytostatic effect in human leukemic cell lines.

Product information

CAS Number: 515-03-7

Molecular Weight: 308.50

Formula: C20H36O2

Chemical Name: (1R, 2R, 4aS, 8aS)-1-((R)-3-hydroxy-3-methylpent-4-en-1-yl)-2, 5, 5, 8a-tetramethyldecahydronaphthalen-2-ol

Smiles: CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@](C)(O)[C@@H]2CC[C@@](C)(O)C=C

InChiKey: XVULBTBTFGYVRC-HHUCQEJWSA-N

InChi: InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 61 mg/mLwarmed(197.73 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts antitumor effects in various cell lines. Sclareol is able to inhibit DNA synthesis induce arrest at the G(0/1) phase of the cycle apoptosis independent of p53 in human breast cancer cell lines. Intra-tumoral injection of Sclareol reduces tumor growth in vivo against breast cancer. Sclareol also exhibits anti-inflammatory activity in LPS-stimulated macrophages by decreasing inflammatory cytokines expression and increasing antioxidant enzyme activity.

In Vivo:

LD50: Rats >5g/kg (i.g.)

References:

  1. Huang GJ, et al. J Nat Prod, 2012, 75(1), 54-59.
  2. Noori S, et al. Cell Immunol, 2010, 263(2), 148-153.
  3. Dimas K, et al. Biomed Pharmacother, 2006, 60(3), 127-133.

Products are for research use only. Not for human use.

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