Sclareol is a diterpene compound with a labdane skeleton, is mainly used as a raw material in the fragrance industry. It shows potent cytotoxic and cytostatic effect in human leukemic cell lines.
CAS Number: 515-03-7
Molecular Weight: 308.50
Chemical Name: (1R, 2R, 4aS, 8aS)-1-((R)-3-hydroxy-3-methylpent-4-en-1-yl)-2, 5, 5, 8a-tetramethyldecahydronaphthalen-2-ol
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 61 mg/mLwarmed(197.73 mM). Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts antitumor effects in various cell lines. Sclareol is able to inhibit DNA synthesis induce arrest at the G(0/1) phase of the cycle apoptosis independent of p53 in human breast cancer cell lines. Intra-tumoral injection of Sclareol reduces tumor growth in vivo against breast cancer. Sclareol also exhibits anti-inflammatory activity in LPS-stimulated macrophages by decreasing inflammatory cytokines expression and increasing antioxidant enzyme activity.
LD50: Rats >5g/kg (i.g.)
- Huang GJ, et al. J Nat Prod, 2012, 75(1), 54-59.
- Noori S, et al. Cell Immunol, 2010, 263(2), 148-153.
- Dimas K, et al. Biomed Pharmacother, 2006, 60(3), 127-133.
Products are for research use only. Not for human use.
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