Fudosteine, also known as Cleanal and SS-320A, is a MUC5AC mucin hypersecretion inhibitor that is used as an expectorant in chronic bronchial inflammatory disorders.
CAS Number: 13189-98-5
Molecular Weight: 179.24
Chemical Name: S-(3-hydroxypropyl)-L-cysteine
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: Insoluble. Water: 36 mg/mL(200.84 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. Fudosteine (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. Fudosteine significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. Fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. Fudosteine treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. Fudosteine significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. Fudosteine scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction.
Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. Fudosteine increases chloride ion concentration in broncho-alveolar lavage of rats.
- Rhee CK, et al. Eur Respir J, 2008, 32(5), 1195-1202.
- Komatsu H, et al. Pulm Pharmacol Ther, 2005, 18(2), 121-127.
- Osoata GO, et al. Chest, 2009, 135(6), 1513-1520.
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