Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.
CAS Number: 519-02-8
Molecular Weight: 248.36
Chemical Name: (1R, 2R, 9S, 17S)-7, 13-diazatetracyclo[220.127.116.11, .0, ]heptadecan-6-one
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 49 mg/mL(197.29 mM). Water: 11 mg/mLwarmed(44.29 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice.
LD50: Mice 157mg/kg (i.p.)
- Wang XY, et al. Nanfang Yike Daxue Xuebao, 2010, 30(9), 2154-2155.
- Higashiyama K, et al. Biol Pharm Bull, 2005, 28(5), 845-848.
- Zhang Y, et al. Cytotechnology, 2009, 59(3), 191-200.
Products are for research use only. Not for human use.
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