Neohesperidin dihydrochalcone

Catalog No. Size PriceQuantity
M7756-2 2mg solid $80
M7756-10 10mg solid $240


Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

Product information

CAS Number: 20702-77-6

Molecular Weight: 612.58

Formula: C28H36O15



Chemical Name: 1-(4-{[(2S, 3R, 4S, 5S, 6R)-4, 5-dihydroxy-6-(hydroxymethyl)-3-{[(2S, 3R, 4R, 5R, 6S)-3, 4, 5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2, 6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one

Smiles: C[C@@H]1O[C@@H](O[C@H]2[C@@H](O[C@H](CO)[C@@H](O)[C@@H]2O)OC2=CC(O)=C(C(=O)CCC3C=C(O)C(=CC=3)OC)C(O)=C2)[C@H](O)[C@H](O)[C@H]1O


InChi: InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL(163.24 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Neohesperidin dihydrochalcone(Nhdc), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus. The product is well known for having a strong synergistic effect when used in conjunction with other artificial sweeteners. As a flavour enhancer, NHDC is used in a wide range of products and is indicated by the E number E 959. It enhances sensory effects by binding human sweet receptor TAS1R2+TAS1R3.


  1. Winnig M, et al. BMC Struct Biol, 2007, 7, 66.
  2. Kroeze JH, Chem Senses, 2000, 25(5), 555-559.

Products are for research use only. Not for human use.

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