Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.
CAS Number: 84-26-4
Molecular Weight: 287.32
Chemical Name: 3, 13, 21-triazapentacyclo[188.8.131.52, .0, .0, ]henicosa-1(21), 2(10), 4(9), 5, 7, 15(20), 16, 18-octaen-14-one
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 24 mg/mL(83.53 mM). Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems.
LD50: Mice 65mg/kg (i.v.).
- Moon TC, et al. Inflamm Res. 1999, 48(12):621-5.
- Yang XW, et al. J Asian Nat Prod Res, 2006, 8(8), 697-703.
- Lee SH, et al. Molecules, 2008, 13(2), 272-300.
Products are for research use only. Not for human use.
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