Catalog No. Size PriceQuantity
M7772-2 2mg solid $90
M7772-10 10mg solid $270


Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.

Product information

CAS Number: 84-26-4

Molecular Weight: 287.32

Formula: C18H13N3O


NSC 258317



Chemical Name: 3, 13, 21-triazapentacyclo[, .0, .0, ]henicosa-1(21), 2(10), 4(9), 5, 7, 15(20), 16, 18-octaen-14-one

Smiles: O=C1C2=CC=CC=C2N=C2C3NC4=CC=CC=C4C=3CCN21


InChi: InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 24 mg/mL(83.53 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems.

In Vivo:

LD50: Mice 65mg/kg (i.v.).


  1. Moon TC, et al. Inflamm Res. 1999, 48(12):621-5.
  2. Yang XW, et al. J Asian Nat Prod Res, 2006, 8(8), 697-703.
  3. Lee SH, et al. Molecules, 2008, 13(2), 272-300.

Products are for research use only. Not for human use.

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