AT-101


Catalog No. Size PriceQuantity
M7801-2 2mg solid $120
M7801-10 10mg solid $360

Description

AT101 is a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines.

Product information

CAS Number: 90141-22-3

Molecular Weight: 518.55

Formula: C30H30O8

Synonym:

Cottonseed Meal Toxin

Gossypol

BL 193

BL-193

BL193

NSC 56817

NSC 624336

Pogosin

(R)-(-)-Gossypol

R-(-)-gossypol acetic acid

AT 101

AT101

Related CAS Number:

12542-36-8 (Gossypol acetic acid)

303-45-7 (Gossypol(RS))

Chemical Name: [2, 2'-Binaphthalene]-8, 8'-dicarboxaldehyde, 1, 1', 6, 6', 7, 7'-hexahydroxy-3, 3'-dimethyl-5, 5'-bis(1-methylethyl)-, (2R)-

Smiles: CC1=CC2C(=C(C=O)C(O)=C(O)C=2C(C)C)C(O)=C1C1=C(O)C2C(C=O)=C(O)C(O)=C(C(C)C)C=2C=C1C

InChiKey: QBKSWRVVCFFDOT-UHFFFAOYSA-N

InChi: InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. [2]. Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.

Products are for research use only. Not for human use.

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