Hordenine


Catalog No. Size PriceQuantity
M7806-2 2mg solid $80
M7806-10 10mg solid $240

Description

Hordenine inhibits the activity of PDK3, inhibits quorum sensing, and acts as an antibiofilm agent against bacteria.

Product information

CAS Number: 539-15-1

Molecular Weight: 165.23

Formula: C10H15NO

Chemical Name: p-(2-Dimethylaminoethyl)phenol

Smiles: CN(C)CCC1C=CC(O)=CC=1

InChiKey: KUBCEEMXQZUPDQ-UHFFFAOYSA-N

InChi: InChI=1S/C10H15NO/c1-11(2)8-7-9-3-5-10(12)6-4-9/h3-6,12H,7-8H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 33 mg/mL(199.72 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Hordenine (N, N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties. It inhibits the uptake of norepinephrine in mammals, working as a stimulant. It is produced in nature by several varieties of plants in the family Cactaceae and by some in Acacia. Recent study shows that hordenine may be an effective inhibitor of hyperpigmentation. it inhibits melanogenesis by suppressing cAMP production, which is involved in the expression of melanogenesis-related proteins.

In Vivo:

LD50: Mice 113.5mg/kg

References:

  1. Kim SC, et al. Food Chem, 2013, 141(1), 174-181.
  2. Barwell CJ, et al. J Pharm Pharmacol, 1989, 41(6), 421-423.

Products are for research use only. Not for human use.

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