Doripenem monohydrate


Catalog No. Size PriceQuantity
M7831-2 2mg solid $85
M7831-10 10mg solid $255

Description

Doripenem Monohydrate, also known as S-4661 and Finibax, is a beta-lactam class drug used for bacterial infections with ultra-broad antibiotic spectrum. Doripenem Monohydrate is used commonly for the treatment of complicated intra-abdominal infections and complicated urinary tract infections.

Product information

CAS Number: 364622-82-2

Molecular Weight: 438.52

Formula: C15H26N4O7S2

Synonym:

S-4661

DRPM

S 4661

S4661

Finibax

Doribax

Related CAS Number:

148016-81-3 (Doripenem free base)

Chemical Name: (4S, 5R, 6R)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S, 5R)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate

Smiles: O.C[C@H]1[C@H]2[C@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]1C[C@H](CNS(N)(=O)=O)NC1)C(O)=O

InChiKey: NTUBEBXBDGKBTJ-WHLATEEKSA-N

InChi: InChI=1S/C15H24N4O6S2.H2O/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25;/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25);1H2/t6-,7+,8+,9-,10-,11-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 36 mg/mL(82.09 mM). Water: 26 mg/mL(59.29 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Doripenem is active against Aeromonas (MIC50, 0.03 mg/L), Bacillus spp. (MIC50, 0.03 mg/L) and all tested anaerobic species (MIC range, 32 mg/L) and Enterococcus faecium (MIC90, >32 mg/L) among the enterococcal species. Doripenem is the most active carbapenem (MIC90, 1 to 4 mg/mL) against penicillin-resistant streptococci. Doripenem is found to be highly active against oxacillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (2705 and 297 isolates, respectively; MIC90s 0.06 mg/L), with a potency greater than that of other carbapenem antibiotics. Doripenem is among the most potent agents tested against Streptococcus pneumoniae, viridans group streptococci and beta-haemolytic streptococci (885, 140 and 397 isolates; MIC(90)s 0.5, 0.5 and 0.03 mg/L, respectively). Doripenem is also active against Citrobacter spp., Enterobacter spp. and Serratia spp. (MIC90s 0.06-0.25 mg/L), including ceftazidime-resistant isolates. Doripenem is slightly more potent (MIC50 2 mg/L) than ertapenem and imipenem (MIC50 4 mg/L), and has a potency similar to that of meropenem (MIC50 2 mg/L), against Burkholderia cepacia (20 isolates). Doripenem demonstrates in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.

References:

  1. Jones RN, et al. J Antimicrob Chemother, 2004, 54(1), 144-154.
  2. Jones RN, et al. Antimicrob Agents Chemother, 2004, 48(8), 3136-3140.
  3. Fritsche TR, et al. Clin Microbiol Infect, 2005, 11(12), 974-984.
  4. Ge Y, et al. Antimicrob Agents Chemother, 2004, 48(4), 1384-13

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed