XL184 (Cabozantinib)


Catalog No. Size PriceQuantity
M7865-2 2mg solid $80
M7865-10 10mg solid $240

Description

Cabozantinib, also known as XL-184 or BMS-907351, is an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several tyrosine receptor kinases. Specifically, cabozantinib appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. Cabozantinib was approved by the U.S. FDA in November 2012 for the treatment of medullary thyroid cancer.

Product information

CAS Number: 849217-68-1

Molecular Weight: 501.51

Formula: C28H24FN3O5

Synonym:

BMS-907351

Cabozantinib free base

Cometriq

Related CAS Number:

1140909-48-3 (Cabozantinib malate)

Chemical Name: N-{4-[(6, 7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1, 1- dicarboxamide

Smiles: COC1=CC2=NC=CC(OC3C=CC(=CC=3)NC(=O)C3(CC3)C(=O)NC3C=CC(F)=CC=3)=C2C=C1OC

InChiKey: ONIQOQHATWINJY-UHFFFAOYSA-N

InChi: InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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