A 922500

A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively. Acyl CoA/diacylglycerol acyltransferase (DGAT) 1 is one of two known DGAT enzymes that catalyze the final and only committed step in triglyceride biosynthesis.

Product information

CAS Number: 959122-11-3

Molecular Weight: 428.48

Formula: C26H24N2O4

Chemical Name: (1R, 2R)-2-(4'-(3-phenylureido)-[1, 1'-biphenyl]-4-carbonyl)cyclopentane-1-carboxylic acid

Smiles: OC(=O)[C@@H]1CCC[C@H]1C(=O)C1C=CC(=CC=1)C1C=CC(=CC=1)NC(=O)NC1C=CC=CC=1

InChiKey: BOZRFEQDOFSZBV-DHIUTWEWSA-N

InChi: InChI=1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.