NVP-ADW742


Catalog No. Size PriceQuantity
M7898-2 2mg solid $100
M7898-10 10mg solid $300

Description

NVP-ADW742, also known as ADW-742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells.

Product information

CAS Number: 475488-23-4

Molecular Weight: 453.58

Formula: C28H31N5O

Synonym:

ADW-742

GSK-552602A

Chemical Name: 5-(3-(benzyloxy)phenyl)-7-((1r, 3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2, 3-d]pyrimidin-4-amine

Smiles: NC1=NC=NC2=C1C(=CN2[C@@H]1C[C@@H](CN2CCCC2)C1)C1=CC(=CC=C1)OCC1C=CC=CC=1

InChiKey: LSFLAQVDISHMNB-AFARHQOCSA-N

InChi: InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)/t21-,23-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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