PKI-587


Catalog No. Size PriceQuantity
M7906-2 2mg solid $90
M7906-10 10mg solid $270

Description

PKI-587is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, PI3K/mTOR kinase inhibitor PKI-587 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

Product information

CAS Number: 1197160-78-3

Molecular Weight: 615.73

Formula: C32H41N9O4

Synonym:

PF-05212384

PF-5212384

Gedatolisib

Chemical Name: 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4, 6-dimorpholino-1, 3, 5-triazin-2-yl)phenyl)urea

Smiles: CN(C)C1CCN(CC1)C(=O)C1C=CC(=CC=1)NC(=O)NC1C=CC(=CC=1)C1N=C(N=C(N=1)N1CCOCC1)N1CCOCC1

InChiKey: DWZAEMINVBZMHQ-UHFFFAOYSA-N

InChi: InChI=1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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