Telatinib (BAY 57-9352)


Catalog No. Size PriceQuantity
M7910-2 2mg solid $90
M7910-10 10mg solid $270

Description

Telatinib, aslo known as BAY 57-9352, is a potent and orally active VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Telatinib treatment was well tolerated. The observed single agent antitumor activity in heavily pretreated CRC patients was limited. Pharmacodynamic results are suggestive for the biological activity of telatinib justifying a further evaluation of telatinib bid in combination with standard chemotherapy regimens in CRC patients.

Product information

CAS Number: 332012-40-5

Molecular Weight: 409.83

Formula: C20H16ClN5O3

Chemical Name: 4-(((4-((4-chlorophenyl)amino)furo[2, 3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide

Smiles: CNC(=O)C1=CC(COC2=NN=C(NC3C=CC(Cl)=CC=3)C3C=COC2=3)=CC=N1

InChiKey: QFCXANHHBCGMAS-UHFFFAOYSA-N

InChi: InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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