DTHIB, HSF1 inhibitor.


Catalog No. Size PriceQuantity
M7980-2 2mg solid $100
M7980-10 10mg solid $300

Description

DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM. DTHIB physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibited the HSF1 cancer gene signature and prostate cancer cell proliferation. In addition, it potently attenuated tumor progression in four therapy-resistant prostate cancer animal models, including an NEPC model, where it caused profound tumor regression.

Product information

CAS Number: 897326-30-6

Molecular Weight: 309.68

Formula: C13H9ClFN3O3

Chemical Name: 1-(4-chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea

Smiles: [O-][N+](=O)C1=CC(=CC=C1Cl)NC(=O)NC1C=CC(F)=CC=1

InChiKey: DWVIOMKFHSRQQM-UHFFFAOYSA-N

InChi: InChI=1S/C13H9ClFN3O3/c14-11-6-5-10(7-12(11)18(20)21)17-13(19)16-9-3-1-8(15)2-4-9/h1-7H,(H2,16,17,19)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Dong B , Jaeger A M , Hughes P F , et al. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1[J]. Science Translational Medicine, 2020, 12(574):eabb5647.

Products are for research use only. Not for human use.

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